Nonbenzamidine compounds as selective factor Xa inhibitors

Bioorg Med Chem Lett. 2000 Aug 7;10(15):1737-9. doi: 10.1016/s0960-894x(00)00316-4.

Authors

W He¹, B Hanney, M R Myers, A P Spada, K Brown, D Colussi, V Chu

Affiliation

¹ Department of Medicinal Chemistry, Aventis Pharmaceuticals, Collegeville, PA 19426, USA. wei.he@aventis.com

PMID: 10937736
DOI: 10.1016/s0960-894x(00)00316-4

Abstract

Nonbenzamidine compounds (imidazole, pyridine, pyrimidine, and thiazole derivatives) as selective serine protease factor Xa inhibitors are discussed.

MeSH terms

Benzamidines / chemistry
Benzamidines / pharmacology
Factor Xa Inhibitors*
Serine Proteinase Inhibitors / chemistry
Serine Proteinase Inhibitors / pharmacology*
Structure-Activity Relationship

Substances

Benzamidines
Factor Xa Inhibitors
Serine Proteinase Inhibitors